Effect of a Single Preoperative Dose of Sublingual Misoprostol on Intraoperative Blood Loss During Total Abdominal Hysterectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180821040844N1

Enrollment

132

Registered

2018-12-06

Start date

2017-10-23

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding during hysterectomy. Intraoperative and postprocedural complications and disorders of genitourinary system, not elsewhere classified

Interventions

Intervention 1: Intervention group: one tablets of misoprostol (200 µg) were administered sublingually one hour before surgery. Intervention 2: Control group: One tablets of vitamin B6 (40 mg) were ad

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patient who were Nominated for Abdominal Hysterectomy due to Benign Gynecologic Disease

Exclusion criteria

Exclusion criteria: Misoprostol Contraindication Malignant Gynecologic Disease

Design outcomes

Primary

Measure	Time frame
?The amount of bleeding during surgery. Timepoint: during surgery (from incision until suturing) and immediately after surgery. Method of measurement: Sum of the measuring the suctioned blood with the absorbed blood in sterile gauzes (assessing the weight difference between bloody gauzes and dry ones).	—

Secondary

Measure	Time frame
Post-operation hemoglobin. Timepoint: 24 hours after surgery. Method of measurement: Blood sample (g/dl).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahideh Astaraei

Iran University of Medical Sciences

vahideh.astaraei@yahoo.com+98 21 8214 1201

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026