Effect of induced muscle ischemia on kidney injury

Evaluation of protective effect of induced muscle ischemia on contrast induced acute kidney injury (CI-AKI) after cardiac angiography or Percutaneous Coronary Intervention (PCI) in cardiac patient admitted at Shahid Mohammadi hospital in 2017-2018

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180820040838N1

Enrollment

140

Registered

2018-10-01

Start date

2016-11-21

Completion date

Unknown

Last updated

2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal dysfunction. Acute renal failure

Interventions

Intervention 1: Intervention group: Remote Ischemic Preconditioning (RIPC) performed via the automated delivery of three cycles of 200 mm Hg blood pressure cuff inflation for 5 min followed by cuff de

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age equal or greater than 18 years Hospitalized patients requiring angiography or PCI

Exclusion criteria

Exclusion criteria: Patients who did not have consent to participate in the study Patients with renal dysfunction (GFR <60) based on KDIGO criteria Pregnant patients Patients who used nephrotoxic drugs 72 hours before angiography or PCI Patients who needed an emergency angiography or PCI Patients with cardiogenic shock, recent cardiac infarction or EF < 50%

Design outcomes

Primary

Measure	Time frame
Serum Creatinine. Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: AutoAnalyzer.;Urine Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Before intervention and 6 hours and 24 hours after intervention. Method of measurement: The enzyme-linked immunosorbent assay (ELISA) kit.;Estimated glomerular filtration rate (eGFR). Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: Modification of diet in renal diseases (MDRD) GFR Equation.;Acute Kidney Injury (AKI). Timepoint: After intervention. Method of measurement: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) criteria.	—

Measure

Time frame

Serum Creatinine. Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: AutoAnalyzer.;Urine Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Before intervention and 6 hours and 24 hours after intervention. Method of measurement: The enzyme-linked immunosorbent assay (ELISA) kit.;Estimated glomerular filtration rate (eGFR). Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: Modification of diet in renal diseases (MDRD) GFR Equation.;Acute Kidney Injury (AKI). Timepoint: After intervention. Method of measurement: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Soleymani

Bandare-abbas University of Medical Sciences

sanazsoleymani9262@gmail.com+98 76 3333 3280

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026