The investigation effect of vitamin D and probiotic co-supplementation on depressive disorder

The effect of vitamin D and probiotic co-supplementation on Brain derived neurotrophic factor (BDNF), High sensitive C reactive protein (hs-CRP) ,depressive disorder ,quality of life and sleep in nurses with depressive disorder ; A double-blind randomized controlled clinical trial.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180818040827N7

Enrollment

Registered

2025-09-08

Start date

2025-08-10

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Depressive disorder. Condition 2: Depressive disorder. Condition 3: Depressive disorder. Major depressive disorder, recurrent, mild Major depressive disorder, recurrent, moderate Major depressive disorder, recurrent severe without psychotic features

Interventions

Intervention 1: Intervention group: This group received a Biozen supplement containing 400IU of vitamin D and a probiotic containing 109×2CFU of each of the species Bacillus coagulans, Lactobacillus r

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: People with mild to severe depressive disorder Individuals who agree to participate in the study Age 20 -55 years

Exclusion criteria

Exclusion criteria: Following specific diets (vegetarian diet affects intestinal flora)

Design outcomes

Primary

Measure	Time frame
Determining and comparing the average serum vitamin D levels in the intervention and control groups before and after the study. Timepoint: Before the start of the intervention and at the end of the intervention (after week 12). Method of measurement: Assay kit.	—

Secondary

Measure	Time frame
Determination and comparison of Brain derived neurotrophic factor (BDNF) levels in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Assay kit.;Determining and comparing the mean High sensitive C reactive protein (hs-CRP) in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Assay kit.;Determining and comparing the average depression score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Beck depression inventory questionnaire (BDI).;Determining and comparing the average quality of life score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: World Health Organization 26-item Quality of Life Questionnaire.;Determining and comparing the average sleep quality score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Pittsburgh Sleep Quality Questionnaire.	—

Measure

Time frame

Determination and comparison of Brain derived neurotrophic factor (BDNF) levels in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Assay kit.;Determining and comparing the mean High sensitive C reactive protein (hs-CRP) in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Assay kit.;Determining and comparing the average depression score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Beck depression inventory questionnaire (BDI).;Determining and comparing the average quality of life score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: World Health Organization 26-item Quality of Life Questionnaire.;Determining and comparing the average sleep quality score in the intervention and control groups, before and after the study. Timepoint: Before and after intervention. Method of measurement: Pittsburgh Sleep Quality Questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactYeganeh Hoveyda

Esfahan University of Medical Sciences

hoveyda.yeganeh77@gmail.com+98 31 3792 3175

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026