Ischemic stroke. Cerebellar stroke syndrome
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive one tablet of Royal Jelly (containing 1000 mg of Royal Jelly powder) daily after breakfast for 12 weeks. Royal Jelly supplement
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: Confirmed diagnosis of ischemic stroke by a neurologist NIHSS score of 5-20 An absence of previous stroke or or MRS score of = 1 for those with previous stroke Ischemic stroke of non-brain stem area age of 45-80 Not following specific dietary regimen in previous 3 months Not taking multivitamins and antioxidant supplements in the previous 3 months Non pregnant and lactating women No other diseases such as acute kidney, liver, heart, other neurological diseases, malignancies, no asthma, allergies and dermatitis Not suffering from mental retardation (mental disabilities) Not taking drugs that interfere with Royal Jelly supplementation (warfarin) Lack of sensitivity and allergy to honey and its products
Exclusion criteria
Exclusion criteria: Unwillingness to continue the study for any reason Adherence of less than 80% to the intervention (taking less than 80% of Royal Jelly supplement that should be taken during the 12 weeks of the intervention will be considered low adherence) Recurrence of stroke Death Use of antioxidant and multivitamin supplements during the study Prescription of warfarin during the study Gastrointestinal side effects or allergies caused by taking Royal Jelly supplement Diagnosis of other diseases such as kidney, autoimmune and malignancies during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Superoxide dismutase. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Glutathione peroxidase. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Malonaldehyde. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Total antioxidant capacity. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Total oxidant status. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Nitric oxide. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetric method.;Brain derived neurotrophic factor. Timepoint: At baseline and after 12 weeks. Method of measurement: ELISA method.;Modified Rankin Scale. Timepoint: At baseline and after 12 weeks. Method of measurement: Questionnaire.;Stroke specific quality of life. Timepoint: At baseline and after 12 weeks. Method of measurement: Questionnaire.;Cognitive function. Timepoint: At baseline and after 12 weeks. Method of measurement: MMSE questionnaire.;Fatigue score. Timepoint: At baseline and after 12 weeks. Method of measurement: FSS questionnaire.;Uric acid. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetry.;C-reactive protein. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetry.;Erythrocyte sedimentation rate. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetry.;Blood pressure. Timepoint: At baseline and after 12 weeks. Method of measurement: sphygmomanometer.;Lipid profile. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetry.;Fasting Blood Glucose. Timepoint: At baseline and after 12 weeks. Method of measurement: Colorimetry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress score. Timepoint: At baseline and after 12 weeks. Method of measurement: DASS-21 questionnaire.;Depression score. Timepoint: At baseline and after 12 weeks. Method of measurement: DASS-21 questionnaire.;Anxiety score. Timepoint: At baseline and after 12 weeks. Method of measurement: DASS-21 questionnaire.;Appetite score. Timepoint: At baseline and after 12 weeks. Method of measurement: SNAQ questionnaire.;Mid arm circumference. Timepoint: At baseline and after 12 weeks. Method of measurement: Tape meter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Amnai
Esfahan University of Medical Sciences
Outcome results
None listed