Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: 500 mg ginger supplements three times a day for 12 weeks. Intervention 2: Control group: 500 mg corn supplements (placebo) three times a day for 12 weeks.
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Having relapsing-remitting multiple sclerosis according to the 2017 revisions of the McDonald diagnostic criteria Age between 18-50 years Non-menopausal women Disability status score of less than or equal to 4.5 based on Expanded Disability Status Scale No multiple sclerosis attack or corticosteroid therapy for at least 30 days No change in multiple sclerosis medications for at least 6 months Ability and willingness to participate in the study
Exclusion criteria
Exclusion criteria: Having other serious diseases such as other autoimmune disorders or cancers Pregnancy Multiple sclerosis attack or corticosteroid therapy during the intervention Change in multiple sclerosis medications during the intervention Allergic reactions to ginger or placebo supplements Consumption of less than 90% of ginger or placebo supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of disability status. Timepoint: Before and after the intervention. Method of measurement: Expanded Disability Status Scale.;Serum levels of interleukin-17. Timepoint: Before and after the intervention. Method of measurement: Assay kit.;Serum levels of nitric oxide metabolites. Timepoint: Before and after the intervention. Method of measurement: Assay kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of neurofilament light polypeptide. Timepoint: Before and after the intervention. Method of measurement: Assay kit.;Serum levels of matrix metalloproteinase-9. Timepoint: Before and after the intervention. Method of measurement: Assay kit.;Differential leukocyte count. Timepoint: Before and after the intervention. Method of measurement: Cell counter machine.;Score of quality of life. Timepoint: Before and after the intervention. Method of measurement: Multiple Sclerosis Impact Scale.;Score of gastrointestinal symptoms. Timepoint: Before and after the intervention. Method of measurement: Visual Analogue Scale.;Hematological indices. Timepoint: Before and after the intervention. Method of measurement: Cell counter machine.;Body mass index. Timepoint: Before and after the intervention. Method of measurement: Weighing scale and measuring tape. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Amani
Esfahan University of Medical Sciences
Outcome results
None listed