Diabetic Polyneuropathy. Type 2 diabetes mellitus with diabetic polyneuropathy
Conditions
Interventions
Intervention 1: Intervention group: 600mg of effervescent tablet of N-acetyi cysteine every12 hours for 8 weeks . Intervention 2: Control group: 75mg of pregabalin every 12 hours for 8 weeks .
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 30 to 70 years old History of DM2 at least one year ago Hb A1C less than or equal to 9 Diabetic Neuropathy with NDS score greater than or equal to 6; VAS Score fore pain at least 4 and NSS score greater than or equal to 5. Glomerular filteration rate more than 30cc/min
Exclusion criteria
Exclusion criteria: Type 1 diabetes Pregnancy or breast feeding Diabetic foot ulcer Neuropathy for reason other than diabetes History of cerebrovascular disease and discopathy Use other medications to relieve symptoms of neuropathy Use of alcoholic drink or opioids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale. Timepoint: Before intervention, the end of the first month and the end of the second month. Method of measurement: Indicator.;Sleep interference score. Timepoint: Before intervention, the end of the first month and the end of the second month. Method of measurement: Questionnaire.;Patient global impression of change. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Questionnaire.;Clinical global impression of change. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFirozeh Sajedi
Hamedan University of Medical Sciences
Outcome results
None listed