Effect of pleurodesis and bleomycin in malignant pleural effusions

Evaluation of success rate of pleurodesis with negative pressure suction and bleomycin in malignant pleural effusions

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180813040779N1

Enrollment

Registered

2018-08-26

Start date

2018-09-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural effusion. Pleural effusion, not elsewhere classified

Interventions

Intervention group: In patients with malignant pleural effusion, 15 ml of lidocaine 2% is injected into the chest tube, and bleomycin 1 mg/kg is injected into the chest tube with 50 ml normal saline t

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Cytologically confirmed malignant pleural fluid No sensitivity to bleomycin No history of previous chemotherapy with bleomycin

Exclusion criteria

Exclusion criteria: Previous history of pleurodesis History of coagulation disorders Patient dissatisfaction

Design outcomes

Primary

Measure	Time frame
The amount of pleural effusion. Timepoint: Before the intervention and four weeks after the intervention. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Rahimian

Yazd University of Medical Sciences

m.rahimian@ssu.ac.ir+98 35 3822 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026