Fibrinogen effect on bleeding rates in surgeries

The Effect of Fibrinogen on Bleeding Rates in Lumbar Surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180811040763N1

Enrollment

Registered

2018-09-01

Start date

2018-08-07

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar discopathy. Lumbar and other intervertebral disc disorders with radiculopathy

Interventions

Intervention 1: Intervention group: At the beginning of surgical incision, Fibrinogen (1 mg) with 50 cc distilled water is administered. Intervention 2: Control group: At the beginning of surgical inc

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients candidate of lumbar surgery Age range: 18 to 60 years old

Exclusion criteria

Exclusion criteria: Patients with cardiovascular diseases Patients with anemia or bleeding disorders Consumption of anticoagulant medications History of spinal surgery

Design outcomes

Primary

Measure	Time frame
Serum fibrinogen level. Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Partial Thromboplastin Time (PTT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Prothrombin Time (PT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Hematocrit (HCT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Hemoglobin (HB). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.	—

Measure

Time frame

Serum fibrinogen level. Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Partial Thromboplastin Time (PTT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Prothrombin Time (PT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Hematocrit (HCT). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.;Hemoglobin (HB). Timepoint: Before anesthesia induction (pre-intervention), immediately, 6 and 24 hours after the completion of the surgical operation. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Shafaei Tonekaboni

Ahvaz University of Medical Sciences

Hosnieh.shafaee@gmail.com+98 61 3374 3001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026