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The effects of alendronate on the function and pain in patients with knee osteoarthritis referred to Rheumatology Clinic

The effects of alendronate on the function and pain in patients with knee osteoarthritis referred to Rheumatology Clinic

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180811040759N5
Enrollment
80
Registered
2023-10-24
Start date
2023-10-07
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Group 1 (40 people) will use alendronite. The duration of treatment will be 2 months, 70 mg will be administered orally weekly. Intervention 2: Control group: Gro

Sponsors

Rafsanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 45-70 years The diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology, which is confirmed by a specialist in hematology

Exclusion criteria

Exclusion criteria: Patients suffering from inflammatory diseases (such as lupus, rheumatoid arthritis, history of brucellosis, etc.) Cancer with serious diseases Symptoms with a history of liver or kidney failure Oral corticosteroid use in the last 4 weeks Cortisone injection in the last 6 months Fever Consuming medicinal plants continuously Unwillingness to continue participating in the study Use of dietary and medicinal supplements Consuming painkillers on a regular daily basis and very advanced disease

Design outcomes

Primary

MeasureTime frame
Knee pain intensity. Timepoint: At the beginning and the end of the study (two months after the beginning of the study). Method of measurement: Visual Analogue Scale (VAS) And WOMAC index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Hassanipour

Rafsanjan University of Medical Sciences

mahsahasanipour@rums.ac.ir+98 34 3428 0040

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026