Lichen Planopilaris. Lichen planopilaris
Conditions
Interventions
Intervention 1: Intervention group: Oral tab naltrexone 3mg once a day at 1 hr before sleep plus topical Clobetasol ointment once at night for 6 months. Intervention 2: Control group: Oral Tab Placebo
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Diagnosis of Lichenplanopilaris (LPP) based on pathology
Exclusion criteria
Exclusion criteria: Burn-out lesions Any treatments for lichenplanopilaris within the last month History of drug addiction or alcohol abuse History of psychiatric disorders Willing to get or being pregnant Consumption of drugs interfering with naltrexone (e.g. opioid antagonists) Generalized cutaneous or mucosal lichen plan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen Planopilaris Acivity Index (LPPAI) Score. Timepoint: before intervention and 2, 4 , 6 months after intervention. Method of measurement: LPPAI Questionnair. | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment tolerance. Timepoint: 2, 4 and 6 months after intervention. Method of measurement: Interview.;ESR. Timepoint: Before intervention and 2, 4 and 6 months after intervention. Method of measurement: Lab kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFereshteh Salarvand
Tehran University of Medical Sciences
Outcome results
None listed