Condition 1: obesity. Condition 2: food addiction. Condition 3: gut microbiota. Obesity due to excess calories
Conditions
Interventions
Intervention 1: Intervention group: 3 months low calorie diet with reduced carbohydrates based on high fiber sources. Intervention 2: Control group: Standard low calorie diet.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to 19 Years
Inclusion criteria
Inclusion criteria: Adolescents 12-19 years old Obese, body mass index higher than 2 standard deviations from the average standard set for age and sex by the World Health Organization for children or adolescents between 5-19 years Has at least 3 signs of food addiction questionnaire symptoms and significant clinical disorder or discomfort Willingness to participate in the study
Exclusion criteria
Exclusion criteria: Taking antibiotics for more than 3 days during the previous 3 months Taking medications or supplements such as probiotics or prebiotics that alter the gastrointestinal microbiota for more than 3 days in the past 1 month Participate in other weight loss programs in the previous 3 months and Suffering from any type of metabolic, renal, cardiovascular, thyroid, liver and gastrointestinal diseases Secondary obesity such as Cushing's syndrome, hypothyroidism, hypogonadal or pituitary obesity History of eating disorders Current use of corticosteroids for more than 5 days a month Use of medications to treat psychosis or manic-depressive illness such as lithium, carbamazepine, valproic acid History of surgery in the last 3 months (history of obesity surgery) History of weight fluctuations of more than 5 kg in the last 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Digital scales.;Body mass index. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: calculation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Average daily intake of unsaturated fatty acids. Timepoint: At the beginning of the study, 45 and 90 days after the start of the intervention (diet). Method of measurement: 24-hour food recall questionnaire.;Fasting serum glucose concentration. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Colorimeter/ laboratory kit.;Fasting serum insulin concentration. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: enzyme-linked immunosorbent assay/laboratory kit.;Total serum cholesterol level. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Colorimeter/ laboratory kit.;Serum triglyceride level. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Colorimeter/ laboratory kit.;Serum Low density lipoprotein level. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: calculation.;Serum high density lipoprotein level. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Blood biochemical test / colorimetry.;Systolic blood pressure. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: sphygmomanometer.;Diastolic blood pressure. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: sphygmomanometer.;Food Addiction Score. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Yale Food Addiction Scale.;Abundance of actionbacteria. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of measurement: Polymerase chain reaction test.;Abundance of firmicutes. Timepoint: At the beginning and end of the study (3 months after starting the diet). Method of m | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactYasaman Khorshidi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed