The effect of vitamin E and C on risk factors of coronary artery disease (CAD)

The effect of vitamin E and C supplements on risk factors of coronary artery disease (CAD) in patients with coronary heart disease

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180804040688N1

Enrollment

Registered

2018-08-15

Start date

2018-09-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease (CAD). Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Vitamin E Group: This group only consumes vitamin E supplement of 600 mg daily for 10 weeks. Intervention 2: Vitamin C Group: This group only consumes vitamin C supplement of 1000 mg d

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclination to participate in research Certification of physician to receive vitamins E and C Age 18 to 50 years old Acceptable listening, speaking and consciousness to answer the questions Waist circumference is more than 102 cm in men and more than 88 cm in women Fasting triglyceride equal to or greater than 150 mg/dl HDL less than 40 mg/dl Systolic blood pressure equal to or greater than 135 mm Hg Fasting glucose is greater than or equal to 110 mg/dl

Exclusion criteria

Exclusion criteria: Not pregnant Do Not taking corticosteroids and contraceptives Lack of underlying diseases (such as kidney and liver failure, thyroid dysfunction, malignancy, mental, autoimmune and infectious diseases) Lack of specific medical conditions requires as a change in diet and exercise program Lack of insulin treatment The need for surgery during the study Cancellation request of the patient Incidence of unwanted side effects Irregular consumption of supplements

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: Before and after the intervention. Method of measurement: Mercury sphygmomanometer.;Lipid profiles. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.;Fasting blood sugar. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.;Body mass index (BMI). Timepoint: Before and after the intervention. Method of measurement: Weight (kilograms) / square height (meter).;C-reactive protein (CRP). Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.	—

Measure

Time frame

Systolic and diastolic blood pressure. Timepoint: Before and after the intervention. Method of measurement: Mercury sphygmomanometer.;Lipid profiles. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.;Fasting blood sugar. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.;Body mass index (BMI). Timepoint: Before and after the intervention. Method of measurement: Weight (kilograms) / square height (meter).;C-reactive protein (CRP). Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajjad Rezaei

Gonabad University of Medical Sciences

sajadrezaeistusurgical009@gmail.com+98 51 3366 4228

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026