Liver Cirrhosis. Fibrosis and cirrhosis of liver
Conditions
Interventions
Intervention 1: Intervention group: Administration of Curcumin 500mg supplement twice a day for 90 days. Intervention 2: Control group: Administration of placebo.
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: MELD Score below 18 PaO2 upper than 60 mmHg without Hepato Cellular Carcinoma Without Hepato pulmonary syndrome Without consumption of antiplatelet and anti coagulant drugs Without Cholelithiasis and Bladder stone
Exclusion criteria
Exclusion criteria: MELD Score above 18 PaO2 less than 60 mmHg Hepato pulmonary syndrome Pulmonary artery pressure above 25mmHg Hyper Oxaluria Hillar cholangio carcinoma Cystic fibrosis with FEV1 less than 40%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MELD (i) Score. Timepoint: Every two week. Method of measurement: MELD (i) Score= 10 * ((0.957 * ln(Creatinine)) + (0.378 * ln(Bilirubin)) + (1.12 * ln(INR)) + 6.43.;Child-Pugh Score. Timepoint: Every two week. Method of measurement: According to formula: Total Bilirubin, INR, Albumin, Ascites, Encephalopathy (Laboratory, Imaging and clinical methods).;MELD Score. Timepoint: Every Two Week. Method of measurement: MELD = MELD(i) + 1.32 × (137 – Na) – [ 0.033 × MELD(i) × (137 – Na) ]. | — |
Secondary
| Measure | Time frame |
|---|---|
| Aspartate Aminotransferase (AST). Timepoint: Once a month. Method of measurement: Laboratory Assay.;Alanine Aminotransferase (ALT). Timepoint: Once a month. Method of measurement: Laboratory Assay.;Alkaline Phosphatase. Timepoint: Once a month. Method of measurement: Laboratory Assay.;Prothrombin Time (PT). Timepoint: Once a month. Method of measurement: Laboratory Method.;Partial Thromboplastin Time (PTT). Timepoint: Once a month. Method of measurement: Laboratory Assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoud Nouri-Vaskeh
Tabriz University of Medical Sciences
Outcome results
None listed