Augmented renal clearance. Abnormal results of kidney function studies
Conditions
Interventions
Intervention 1: Intervention group: patients will be received intravenous vancomycin manufactured by Exir pharmaceutical company at dose of 15 to 20 mg/kg every 12 hours. The infusion rate of vancomyc
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years old Need of vancomycin therapy with empirical approach or according to the culture Augmented renal clearance (ARC) score between 7 and 10 Augmented renal clearance in trauma intensive (ARCTIC) score over than 6 Signing the informed consent form
Exclusion criteria
Exclusion criteria: Blood creatinine level lower than 1.5 mg/dL Pregnant or breastfeeding patients Patients with history of vancomycin hypersensitivity Patients with history of vancomycin taking in the current course of hospitalization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of patients with Area under the curve (AUC)/Minimum inhibitory concentration (MIC) over 400. Timepoint: Three days after initiation of intervention. Method of measurement: High performance liquid chromatography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood trough level of vancomycin. Timepoint: Three days after initiation of intervention. Method of measurement: High performance liquid chromatography.;Getting acute kidney injury. Timepoint: Seven days after initiation of intervention. Method of measurement: Measurement of creatinine blood level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Sahraei
Shahid Beheshti University of Medical Sciences
Outcome results
None listed