Osteoarthritis grade 1 to 3. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group 1: Cream derived from secretions of adipose tissue-derived mesenchymal stem cells. Intervention 2: Control group: Base cream (placebo), Using a Dr. Zilla brand moist
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 30 years and above Pain in at least one knee for the past three months Mild to moderate osteoarthritis (grades 1 to 3) Presence of moderate to minimally bothersome pain based on visual pain criteria for at least four weeks prior to admission Body mass index less than or equal to 30 Patient's willingness to participate in the study
Exclusion criteria
Exclusion criteria: Use of oral and topical steroids within 14 days prior to the study Intra-articular steroid injection within 90 days prior to the study Taking antioxidant supplements and anti-anxiety and anti-depressant medications at least 1 month ago Having balance disorders Patient's interruption of testing Osteoarthritis secondary to rheumatological diseases such as rheumatoid arthritis, gout, infectious arthritis, metabolic arthritis, traumatic arthritis Knee replacement surgery during testing Patient participation in other motor rehabilitation programs Acute inflammatory diseases, infectious diseases, and malignancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of pain in the affected joint. Timepoint: This variable indicates the patient's level of pain in the osteoarthritis joint.It is done before and after 8 weeks. Method of measurement: Pain intensity is measured using a Visual Analog Scale (VAS), which is rated from 0 to 10.;Function of the affected joint. Timepoint: This variable indicates the patient's level of motor and functional ability in daily activities. It is done before and after 8 weeks. Method of measurement: Performance is measured using the validated WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of skin side effects. Timepoint: In order to assess the safety of the product, all possible skin reactions (such as redness, itching, burning, or inflammation at the site of application of the cream) are recorded and reported by the researcher. Method of measurement: This assessment is done at each follow-up visit.Standard skin reaction monitoring checklist including items to assess the severity of redness, itching, burning, swelling, and other skin reactions.The severity of each reaction is recorded on a 4-point scale:No symptoms - Mild - Moderate - Severe. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Emamirazavi
Tehran University of Medical Sciences
Outcome results
None listed