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Effect of N-acetylcysteine in the improvement of Aphthous

Evaluation of the effectiveness of N-acetylcysteine mucosa adhesive in comparison with placebo on recurrent aphthous stomatitis (RAS) in the specific age group 16-45 years old

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180728040614N1
Enrollment
46
Registered
2018-09-29
Start date
2018-09-23
Completion date
Unknown
Last updated
2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent aphthous stomatitis. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group: Patients received mucoadhesive tablets three times a day containing N-acetylcysteine (morning, afternoon and night). How to use a mucoadhesive tablet was taught to

Sponsors

Sari University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age group 16 to 45 years old Diagnostic criteria for aphthous stomatitis sufficient knowledge to understand the description provided for treatment Legally the patients are able to complete their consent form

Exclusion criteria

Exclusion criteria: People who take suppressive drugs during the past month People with Systemic Disease People with syndromes such as Behcet's syndrome, which aphthous ulcer is one of the manifestations . Patients who develop aphthous ulcers in areas other than labial and buccal mucosa People with recurrent stomatitis Herpes form People with recurrent major aphthous stomatitis Patients with poor oral hygiene Pregnant women Antibiotic users Patients with dentures People who use other drugs to treat aphthous ulcer and in general people who cant stay or cant continue cooperation till end of research due to personal and social reasons Smoking Individuals

Design outcomes

Primary

MeasureTime frame
Diameter of eritmathous halo. Timepoint: Days zero (before entering the study); third; fifth and seventh. Method of measurement: Metal caliber.;Period of improvement. Timepoint: Days zero (before entering the study); third; fifth and seventh. Method of measurement: Visual Analogue Scale Questionnaire.

Secondary

MeasureTime frame
The amount of pain. Timepoint: Days zero (before entering the study); third; fifth and seventh. Method of measurement: Visual Analogue Scale Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnahita Ghorbani

Sari University of Medical Sciences

anahita1802@yahoo.com0098_114001 3304

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026