The effect of carnitine on liver function

Evaluation of the effectiveness of oral L-carnitine on liver function in children undergoing congenital heart defect repair surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180724040575N2

Enrollment

Registered

2020-09-28

Start date

2019-10-23

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery for repair of congenital heart lesions.

Interventions

Intervention 1: Intervention group: Administration of 100 mg / kg oral L-carnitine, the night before surgery. Intervention 2: Control group: Administration of 1 ml per kg oral serum of normal saline,

Eligibility

Sex/Gender

All

Age

6 Months to 60 Months

Inclusion criteria

Inclusion criteria: Age 6 to 60 months Cardiac repair surgery under the pump Conscious consent of parents

Exclusion criteria

Exclusion criteria: Off pump operation Known allergy to L-carnitine Severe liver failure (liver enzymes more than twice normal) Emergency operation

Design outcomes

Primary

Measure	Time frame
Alanine aminotransferase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Aspartate aminotransferase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Alkaline phosphatase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Lactate dehydrogenase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Bilirubin. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Albumin. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Prothrombin time. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Partial thromboplastin time. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;International normalization ratio. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.	—

Measure

Time frame

Alanine aminotransferase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Aspartate aminotransferase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Alkaline phosphatase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Lactate dehydrogenase. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Bilirubin. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Albumin. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Prothrombin time. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;Partial thromboplastin time. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.;International normalization ratio. Timepoint: Before, the first and seventh day after surgery. Method of measurement: Measuring the amount in the blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamal Fani

Shahid Beheshti University of Medical Sciences

kamalfani@sbmu.ac.ir+98 21 2207 4095

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026