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Evaluation the safety of treatment of damaged corneal surface through ocular stem cell transplantation

Cultivation of limbal stem cells on poly-tetra-fluoro-ethylene (PTFE) scaffold , transplantation in patients with limbal stem cell deficiency (LSCD) and study of the effect of transplantation on visual acuity and improvement of eye surface condition

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180724040574N1
Enrollment
10
Registered
2020-05-06
Start date
2020-05-19
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal limbal stem cell deficiency. Complications of stem cell transplant

Interventions

Corneal Limbal Stem Cell Transplantation: Corneal stem cells placed on the carrier are transferred to the patient's corneal surface. For this purpose, the patient's corneal surface is prepared for tra

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients (without age restriction) who suffer from corneal limbal stem cell defect and have not responded to initial treatment. The patient's severe need to correct the vision of one eye due to bilateral conflict.

Exclusion criteria

Exclusion criteria: The normality of corneal surface cells in corneal surface examination Suffering from diseases such as hepatitis and AIDS Having advanced glaucoma and the need to use several eye drops Any other eye disease that, despite clear cornea, prevents vision improvement

Design outcomes

Primary

MeasureTime frame
Corneal clarity. Timepoint: Before transplantation and 3 months after the transplantation. Method of measurement: Grading of opacity with slit lamp examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoomeh Eghtedari

Shiraz University of Medical Sciences

eghtedarim@sums.ac.ir+98 71 3629 1779

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026