Effect of gabapentin, pregabalin and oral celecoxib on controlling of postoprative pain in orthopaedic lower extremities surgrey

Comparison of the prophylactic effects of gabapentin, pregabalin and oral celecoxib and placebo on controlling of postoperative pain in orthopaedic lower extremities surgery with spinal anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180722040557N1

Enrollment

120

Registered

2018-08-07

Start date

2018-08-11

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain of lower limb following orthopaedic lower limb surgery. Pain in limb, hand, foot, fingers and toes

Interventions

Intervention 1: Intervention group: One hour prior to spinal anesthesia group 1 received 300 mg gabapentin,. Intervention 2: Intervention group: One hour prior to spinal anesthesia group 2 received

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Candidacy of elective lower limb orthopaedic surgery No contraindication for spinal anesthesia No restriction for sitting position Patient's tendency to spinal anesthesia No risk of increasing intra cranial pressure No suffering from uncontrolled diseases No coagulation disorders

Exclusion criteria

Exclusion criteria: Patient's dissatisfaction to keep on coopration Failling of spinal anesthesia (it was tried twice maximally)

Design outcomes

Primary

Measure	Time frame
Post orthopedic sergical pain of the lower extremities. Timepoint: Each 60 minutes for 2 times and each 6 hours for the next 4 times. Method of measurement: Visual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzie Taghvaie

Esfahan University of Medical Sciences

dr.taghvaie@gmail.com+98 31 5321 5240

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026