The efficacy of neutralizing heparin by prothamine in cardiac open heart surgery

The efficiency and effectiveness of the ACT, ROTEM protocol for neutralizingprotamine heparin in adult patients with open heart surgery (CABG) at ShahidRajaee Cardiovascular Research and Treatment Center

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

IRCT

Registry ID

IRCT20180719040524N1

Enrollment

Registered

2019-07-23

Start date

2018-10-23

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart disease. Atherosclerosis

Interventions

Intervention 1: Our intervention group on the day of operation after taking the anesthetic is taken from the ACT patient at the start of the procedure, and then 3mg / kg heparin is given to prepare th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who do not have an anticoagulant drug Patients undergoing surgery for the first time

Exclusion criteria

Exclusion criteria: Patients with a history of heart surgery Patients with coagulation disorders Patients with liver and kidney failure

Design outcomes

Primary

Measure	Time frame
To investigate more precisely the blood factors and the results of neutralizing the effects of anticoagulant drugs used during surgery, we use the ROTEM device. Timepoint: At the end of the operation, if necessary, an observer will be used. Method of measurement: By ROTEM.;Our primary variable is the patient's activated clotting time (ACT). Timepoint: ACT is taken from the beginning of the surgery every hour and ACT is taken at the end of the operation, after neutralizing the effect of heparin ACT. Method of measurement: Measured by ACT.	—

Measure

Time frame

To investigate more precisely the blood factors and the results of neutralizing the effects of anticoagulant drugs used during surgery, we use the ROTEM device. Timepoint: At the end of the operation, if necessary, an observer will be used. Method of measurement: By ROTEM.;Our primary variable is the patient's activated clotting time (ACT). Timepoint: ACT is taken from the beginning of the surgery every hour and ACT is taken at the end of the operation, after neutralizing the effect of heparin ACT. Method of measurement: Measured by ACT.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mostafa Alavi

Islamic Azad University

aliasghaffari@gmail.com+98 21 23921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026