Uremic pruritus in patients with chronic kidney disease under hemodialysis. Chronic kidney disease, stage 5
Conditions
Interventions
Intervention 1: Intervention group: in this group, each patient will receive two soft gel capsules of 5mg Melatonin after dinner a long with other anti pruritus treatments for 2 weeks (first phase). A
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Hemodialysis Patients equal and more than 18 years old with uremic pruritus Obtain informed consent Patients
Exclusion criteria
Exclusion criteria: Patients with seizure who have taking anti epileptic drugs. Patients with history of melatonin intolerance or allergy reactions to melatonin. Pregnancy and lactation Drug- drug intractions with other medications"anticoagulants,fluvoxamine,immunosappressive drugs" Patients with itchy-dermatology disease, liver disease and cancer Sensitive jobs require high concentration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of pruritus. Timepoint: At the baseline (before intervention) and at the end of 2th, 3th and 5th weeks of intervention. Method of measurement: 12-Item Pruritus Severity Scale.;Severity of pruritus. Timepoint: At the baseline(before intervention) and at the end of 2th, 3th and 5th weeks of intervention. Method of measurement: Visual analogue scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParia Baharvand
Tehran University of Medical Sciences
Outcome results
None listed