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Effect of oral multi-herbal preparation on COVID-19

Formulation and evaluation of their efficacy of herbal capsule and decoction in patients with COVID-19 via a randomized clinical trial.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180712040449N2
Enrollment
68
Registered
2020-04-01
Start date
2020-03-23
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. Covid-19

Interventions

Intervention 1: Intervention group: 34 patients receive herbal treatment including 150 ml of decoction (Matricaria chamomilla L., Zataria multiflora Boiss., Glycyrrhiza glabra L., Ziziphus jujuba Mill

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with one or more of the following symptoms in addition to acute respiratory disease (ARI):• RR> 30• PO2 <93%• Pulmonary infiltration in chest x-ray• Clinical judgment of a specialist Age range of 18 to 75 years in both genders Lack of any serious concomitant disease of the heart, brain, or lungs, metabolic disorders, and etc. The patient’s ability and own will to fill out a personal consent form for inclusion in the study Patient not intubated.

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Any history of allergy to any of the herbal product components Inability to take a drug per-oral Any condition that precludes continuance of medical intervention based on the judgment of a physician. Need for intubation Nausea and vomiting and oral intolerance Resistant hypoxemia Reduced level of consciousness Hemodynamic instability Hypercapnia - respiratory fatigue Any manifestation of known side effects of any of the herbal product components

Design outcomes

Primary

MeasureTime frame
O2 saturation percentage. Timepoint: Clinical examination and pulse oximetry at baseline, days 3, 6, 9, 12 and 14. Method of measurement: Pulse Oximeter.;Lung inflammation. Timepoint: CT scan at baseline, days 7 and 14. Method of measurement: CT scan.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad Karimi

Tehran University of Medical Sciences

mehrdadkarimi@yahoo.com+98 21 8897 6527

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026