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Investigating ovulation stimulation with the combination of GnRH agonist and HCG in polycystic ovary syndrome

Comparative investigation of pregnancy outcomes by ovulation stimulation with GnRH agonist with and without adding HCG in women with polycystic ovarian syndrome in IVF cycles.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180708040381N4
Enrollment
60
Registered
2024-05-02
Start date
2024-05-04
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: HCG + decapeptyl - in group A, a dose of 1500 units of HCG is prescribed 12 hours after the trigger with (decapeptyl) triptorelin sc. Intervention 2: Control group:

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 38 Years

Inclusion criteria

Inclusion criteria: Selection of women with PCOS based on ESHRE ASRM Rotterdam criteria Stimulation with GnRH antagonist protocol Age 20-38 years E2 concentration > 2500 international units on the trigger day Body mass index > 18 and < 30 Having an indication for IVF or ICSI Willingness to participate in the study

Exclusion criteria

Exclusion criteria: severe cause of male infertility Uterine anomalies Severe endometriosis metabolic disease (e.g. metabolic syndrome) Age above 38 and below 20 years Patients with hypogonadism, hypogonadotropism Patients with underlying diseases such as thyroid, hyperprolactinemia, Cushing's syndrome, ovarian and adrenal tumors, diabetes, etc.

Design outcomes

Primary

MeasureTime frame
Number of mature oocytes. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Trans vaginal ultrasound.;Number of retrieved oocytes. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Trans vaginal ultrasound.;The number of blastocysts. Timepoint: Two weeks after administration of Decapeptil. Method of measurement: Abdominal ultrasound.

Secondary

MeasureTime frame
Positive pregnancy test. Timepoint: 4 weeks after IVF. Method of measurement: Beta HCG test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Atena Khayambashi

Esfahan University of Medical Sciences

atena_khayambashi2@yahoo.com+98 31 3236 7001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026