Effect of PLISSIT and bupropion on the sexual dysfunction of men treated with methadone

Determining the efficacy of PLISSIT as adjuvant therapy with bupropion on sexual dysfunction and marital satisfaction among male patients on methadone maintenance therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180704040336N1

Enrollment

Registered

2018-12-11

Start date

2017-09-23

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Substance-induced sexual dysfunction. Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction

Interventions

Intervention 1: Intervention group: Adding PLISSIT to bupropion to increase sexual function and marital satisfaction of patients and respond to their questions: In this intervention, six sessions (wee

at this point, specific suggestions are provided to solve the patient's problems, and then on the sixth week: IT = Intensive Therapy, special treatment for each patient is considered based on the issu

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Complaints of sexual dysfunction Lack of constitutional underlying disease affecting sexual function (based on history), e.g. epilepsy Lack of diabetes Lack of cerebral palsy syndrome Lack of psychosis Lack of using drugs which affect sexual function (based on the history) including: SSRIs, sildenafil, oral or injectable testosterone, antipsychotics, cyclic antidepressants, MAO-I, lithium, amphetamines, chlordiazepoxide, clonidine, methyldopa, spironolactone, hydrochlorothiazide, barbiturates, antiparkinson drugs, clofibrate, digoxin, Indomethacin, propranolol, phentolamine, lack of using stimulants No alcohol use A total score of 19 or more in Arizona Sexual Experiences Scale (ASEX) or a score of 5 or more in one of the items of ASEX or a score of 4 or more in one of the 3 items Patients’ informed consent for participation in the study Being treated with Methadone

Exclusion criteria

Exclusion criteria: Decision of the therapist to discontinue treatment with bupropion or methadone for any reason Unwillingness to participate in the study

Design outcomes

Primary

Measure	Time frame
Sexual dysfunction score based on ASEX questionnaire. Timepoint: At the beginning of the study (before the intervention) and then six weeks after the end of the PLISSIT intervention. Method of measurement: Arizona Sexual Experiences Scale (ASEX) Questionnaire.;Marital incompatibility score based on RDAS questionnaire. Timepoint: At the beginning of the study (before the intervention) and then six weeks after the end of the PLISSIT intervention. Method of measurement: RDAS Marital incompatibility questionnaire.	—

Measure

Time frame

Sexual dysfunction score based on ASEX questionnaire. Timepoint: At the beginning of the study (before the intervention) and then six weeks after the end of the PLISSIT intervention. Method of measurement: Arizona Sexual Experiences Scale (ASEX) Questionnaire.;Marital incompatibility score based on RDAS questionnaire. Timepoint: At the beginning of the study (before the intervention) and then six weeks after the end of the PLISSIT intervention. Method of measurement: RDAS Marital incompatibility questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKurosh Shirani

Esfahan University of Medical Sciences

kurosh.shl100@gmail.com+98 31 3220 8081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026