Comparison of DGC/Zeta vs DGC to Improve of Clinical Outcome in Infertile Patients following ICSI;

Comparison of the Effetiveness of DGC/Zeta New Strategy vs DGC to Improve of Clinical Outcome in Infertile Patients following ICSI; Single Blind Randomised Clinical trail

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180628040270N1

Enrollment

240

Registered

2018-07-25

Start date

2018-04-19

Completion date

Unknown

Last updated

2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evaluation clinical outcomes of two sperm selection methods DGC/Zeta and DGC in male factor infertility candidate for ICSI setting. Male infertility

Interventions

Intervention 1: Control group: DGC routin perm separation method,separation by used gradients 80,40 by commercial material pure sperm. Intervention 2: Intervention group: Combination of DGC/Zeta sperm

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Female age of between 20- 40 years At least one semen parameter of their partner was below nor¬mal threshold presence of at least 2 - 3 follicles = 18 mm in diameter

Exclusion criteria

Exclusion criteria: Women with poor ovarian response, Polycistic ovarian syn. En¬dometriosis,

Design outcomes

Primary

Measure	Time frame
Fertilization rate: Around 16–18 h post-ICSI, fertilization was assessed by the presence of pronuclei.a clear trend towards a better fertilization rate was found in the DGC/Zeta procedure compare to DGC alone. Timepoint: 16–18 h post-ICSI. Method of measurement: The fertilization rate was calculated from the ratio of fertilized oocytes to the total number of survived injected metaphase II oocytes, multiplied by 100 in both groups.;Top quality embryo if there were 6–8 blastomeres on day 3.The score of transferred embryos appeared to be significantly higher in the DGC/Zeta group when compared with the control group. Timepoint: On day 2 and 6–8 blastomeres on day 3. Method of measurement: With fragmentation less than 25% and the total absence of multinucleated blastomeres at any stage of early cleavage.	—

Measure

Time frame

Fertilization rate: Around 16–18 h post-ICSI, fertilization was assessed by the presence of pronuclei.a clear trend towards a better fertilization rate was found in the DGC/Zeta procedure compare to DGC alone. Timepoint: 16–18 h post-ICSI. Method of measurement: The fertilization rate was calculated from the ratio of fertilized oocytes to the total number of survived injected metaphase II oocytes, multiplied by 100 in both groups.;Top quality embryo if there were 6–8 blastomeres on day 3.The score of transferred embryos appeared to be significantly higher in the DGC/Zeta group when compared with the control group. Timepoint: On day 2 and 6–8 blastomeres on day 3. Method of measurement: With fragmentation less than 25% and the total absence of multinucleated blastomeres at any stage of early cleavage.

—

Secondary

Measure	Time frame
Clinical pregnancy rate with heart beat was defined from ultrasonography findings showing at least one embryo with a fetal heart beat 5 weeks after transfer. Timepoint: 5 weeks after transfer.findings atleast one embryo with a fetal heart beat. Method of measurement: With ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hossein Nasr Esfahani

Royan Institute Tehran

mh_nasr@med.mui.ac.ir+98 21 2356 2123

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 18, 2026