Female infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group:In addition to estradiol valerate (6 mg orally daily
10 days), this group receives one probiotic vaginal capsule daily for two weeks from the start of endometrial preparation for embryo transfer. Intervention 2: Control group:This group does not receive
10 days).
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Being non-menopausal Being married Aged 40 and below years History of unexplained RIF (three or more consecutive failed ETs with good quality embryos) Having a normal uterine cavity Having a both ovaries Having an adequate endometrial thickness and pattern
Exclusion criteria
Exclusion criteria: Having vaginal bleeding Having vaginitis History of utero-cervical anomalies, endometriosis, chronic diseases, or endocrinopathies (like adrenal insufficiency or uncontrolled thyroid dysfunction) Chromosomal abnormalities (either parents or previously transferred embryos) Smoking Taking antibiotics during the past 2 wk Taking vaginal medications during the past 2 wk Taking vaginal douche during the past week
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy. Timepoint: Four Weeks after embryo transfer (four weeks after the end of the intervention). Method of measurement: Trans-vaginal Ultrasound.;Lactobacillus Level. Timepoint: Immediately after the end of the intervention (2 weeks after starting intervention). Method of measurement: The Evaluation of Lactobacillus with Gram - Staining. | — |
Primary
| Measure | Time frame |
|---|---|
| Chemical Pregnancy. Timepoint: Two weeks after embryo transfer (two weeks after the end of the intervention). Method of measurement: Positive Pregnancy Test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaedeh Ahmadi Dastjerdi
Tehran University of Medical Sciences
Outcome results
None listed