Effect of zinc supplementation in patients undergoing hemodialysis

The effect of zinc supplementation on appetite status, biochemical parameters and food intake in patients with chronic renal failure under hemodialysis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180621040177N1

Enrollment

Registered

2018-11-19

Start date

2016-11-14

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with chronic renal failure under hemodialysis. Chronic kidney disease (CKD)

Interventions

Intervention 1: Intervention group: one capsule containing 220 mg zinc sulfate with 50 mg elemental zinc per day, for 60 days, prepared by Al Hawi Tehran Pharmaceutical Company. Intervention 2: Contro

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age between 20-80 years At least 6 months of hemodialysis 2-3 with hemodialysis per week No problems in eating and indigestion Non-use of any multivitamin and minerals Lack of hospitalization or hospitalization during the study Lack of infection, liver failure, cancer, thyroid problem when entering or during study

Exclusion criteria

Exclusion criteria: Unwilling to participate in the study

Design outcomes

Primary

Measure	Time frame
Dry weight. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: seca scales.;Blood urea nitrogen. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer, enzymatic assay.;Creatinine. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer, enzymatic assay.;Calcium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Phosphorus. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Potassium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Sodium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Blood pressure. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: Gauge pressure gauge.;Food intake. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: 2-day 24-h diet recall.	—

Measure

Time frame

Dry weight. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: seca scales.;Blood urea nitrogen. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer, enzymatic assay.;Creatinine. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer, enzymatic assay.;Calcium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Phosphorus. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Potassium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Sodium. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: autoanalyzer.;Blood pressure. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: Gauge pressure gauge.;Food intake. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: 2-day 24-h diet recall.

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Secondary

Measure	Time frame
Appetite Status. Timepoint: At the beginning of the study and 60 days after taking zinc supplement or placebo. Method of measurement: 2-day 24-h diet recall.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoumeh Akhlaghi

Shiraz University of Medical Sciences

msm.akhlaghi@gmail.com+98 71 3725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026