Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: receive an Risperidone 8mg/day plus Citalopram 20mg/day for 8 weeks. Intervention 2: Control group: receive an Risperidone 8mg/day for 8 weeks.
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Diagnosis of Schizophrenia according to DSM5 criteria and clinical interview by psychiatrist Age range 15-65 years Ability to provide informed consent and cooperation with study procedures At least, 5 years history of schizophrenia Participants needed to be currently taking an Atypic antipsychotic agent for 6 month prior to study Based on the HAM-D scale, having a score of less than 20
Exclusion criteria
Exclusion criteria: Patients under treatment with clozapin Any sever mental disorder(major depressive disorder, psychotic symptoms, manic phase symptoms,…) Renal, hepatic, thyroid, or hematological disorder; and any sever and chronic medical disorder Pregnancy or lactation Individuals on antidepressants treatment for other indications (Tricyclic antidepressant , MAO inhibitor ,Selective serotonine reuptake inhibitor,… )for 1 month prior to randomization Prior history of convulsion , stroke and head trauma History of mental retardation (IQ less than 70) History of substance abuse or dependence within 6months prior to study participation (except nicotine or caffeine dependence)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of positive and negative symptom of Schizophrenia. Timepoint: Before intervention (first visit) ,the end of the fourth week (second visit),the end of the eighth week (third visit). Method of measurement: At each visit to the SANS and SAPS testing will be completed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression-Improvement. Timepoint: End of eight weeks. Method of measurement: CGI Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSafar Hamednia
Oroumia University of Medical Sciences
Outcome results
None listed