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Investigation the effect of cognitive and motor exercises on improving the performance of chronic stroke patients

Investigation the effect of environment?al exercises (physical and virtual reality environment) on the brain reorganization, molecular parameters and behavioral functions (cognitive and motor) in the chronic stroke patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180619040156N1
Enrollment
3
Registered
2018-10-20
Start date
2018-10-29
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic stroke. Family history of stroke

Interventions

Intervention 1: Intervention group: Stroke patients receiving cognitive-motorized physical training in the physical environment and rehabilitation routine interventions. Intervention 2: Intervention g

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Experience the first stroke Passed for 6-24 months after lesion Having ages between 35-65 years Ability to walk at least 10 meters without auxiliary equipment No history of falling over the past 6 months according to the patient's own report Having an acceptable level of cognitive performance means a score of over 24 in the Mini Mental Status Examination (MMSE) test. Not having hemi neglect using the Star Cancellation test Not having any history of other neurological problems, orthopedics and upper limb surgeries involved according to medical records, patient's or patient's report or observation of the examiner Having the criteria for receiving and consuming Atorvastatin drug on the basis of a neurologist's diagnosis Central cerebral artery injury as the cause of stroke Ability to read and write Having understandable speech The lack of vision problems has not been resolved

Exclusion criteria

Exclusion criteria: Falling during assessments and exercises Failure to cooperate properly and correct implementation of the instructions during the tests and exercises.

Design outcomes

Primary

MeasureTime frame
Balance and upper and lower extremity mobility assessments (behavioral tests). Timepoint: Before interventions, immediately after intervention, 3 months after intervention. Method of measurement: Timed up go test, functional reach test, berg test, fugl meyer test.;Cognitive Assessments (Behavioral Tests). Timepoint: Before interventions, immediately after intervention, 3 months after intervention. Method of measurement: Wechsler test, Wisconsin test, Stroop test.;Serum levels of brain-derived growth factor (molecular laboratory tests). Timepoint: Before interventions, immediately after intervention, 3 months after intervention. Method of measurement: Brain derived neurotrophic factor analysis.;Structural changes in various brain regions (laboratory imaging test). Timepoint: Before interventions, immediately after intervention, 3 months after intervention. Method of measurement: magnetic resonance imaging.

Secondary

MeasureTime frame
Changes in fear of falling. Timepoint: Before and after intervention and 3 months after intervention. Method of measurement: Activities-based balance confidence scale (ABC).;Quality of life score. Timepoint: Before and after intervention and 3 months after intervention. Method of measurement: Short Form (36) Health Survey (SF-36).;Changes in fatigue levels. Timepoint: Before and after intervention and 3 months after intervention. Method of measurement: Multidimensional Fatigue Symptom Inventory-Short Form.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoheila Fallah

Iran University of Medical Sciences

fallah.s@tak.iums.ac.ir+98 21 8862 2687

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026