Investigation of the effects of curcumin in patients hospitalized at intensive care unit

Investigation of the Effects of Curcumin Supplementation on Inflammatory, Oxidative stress and Adipokine Markers and Nutritional and Clinical status in Traumatic Brain Injury Patients Receiving Enteral Nutrition at Intensive Care Unit

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180619040151N1

Enrollment

Registered

2018-09-18

Start date

2018-11-02

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury. Diffuse traumatic brain injury

Interventions

Intervention 1: Intervention group: This group will receive 500 mg curcuminoids in combination with 5 mg piperine (produced by Sabinsa company) added to enteral nutrition formula for 7 days. Because

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Being at the age of 18-65 years old Admission to ICU due to head trauma Signing consent form by patient or first degree relatives Glascow coma score equal to 7 or more

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Septic patients who are hemodynamically and metabolically unstable Patients who are not allowed to receive nutritional support in the first 24-48 hours History of any kind of autoimmune disorders History of cancer Chemotherapy and radiotherapy within previous month Receiving positive inotropic agents including dopamine, dobutamine and epinephrine History of any kind of liver failures Severe and active hemorrhage History of AIDS History of known food allergy Morbid obesity (BMI>40)

Design outcomes

Primary

Measure	Time frame
Serum concentration of IL-6. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of TNF-a. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of MCP-1. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of CRP. Timepoint: The first and 8th day of the study. Method of measurement: By Immunoturbidimetry method.;Serum concentration of glutathione peroxidase. Timepoint: The first and 8th day of the study. Method of measurement: By Colorimetric method.;Serum concentration of superoxide desmutase. Timepoint: The first and 8th day of the study. Method of measurement: By Colorimetric method.;Serum concentration of leptin. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of adiponectin. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;NUTRIC score. Timepoint: The first and 8th day of the study. Method of measurement: By questionnaire.;SOFA score. Timepoint: The first and 8th day of the study. Method of measurement: By questionnaire.	—

Measure

Time frame

Serum concentration of IL-6. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of TNF-a. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of MCP-1. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of CRP. Timepoint: The first and 8th day of the study. Method of measurement: By Immunoturbidimetry method.;Serum concentration of glutathione peroxidase. Timepoint: The first and 8th day of the study. Method of measurement: By Colorimetric method.;Serum concentration of superoxide desmutase. Timepoint: The first and 8th day of the study. Method of measurement: By Colorimetric method.;Serum concentration of leptin. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;Serum concentration of adiponectin. Timepoint: The first and 8th day of the study. Method of measurement: By ELISA method.;NUTRIC score. Timepoint: The first and 8th day of the study. Method of measurement: By questionnaire.;SOFA score. Timepoint: The first and 8th day of the study. Method of measurement: By questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHoda Sadat Zahedi

Tehran University of Medical Sciences

hoda.s.zahedi@gmail.com+98 21 8898 4837

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 17, 2026