In Vitro Maturation of oocyte

?Feasibility evaluation of secretome obtained from menstrual blood derived stem cells accompanied with melatonin and follicular fluid in oocyte maturation of patients with polycystic ovary syndrome (PCOS).

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180619040147N8

Enrollment

Registered

2021-10-19

Start date

2021-10-12

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: In Vitro Maturation of oocyte. Condition 2: Polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention group: Immature oocytes.

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Polycystic ovary syndrome patients No background disease At least 4 immature oocyte Anti Mullerian hormone (AMH) higher than 1.3 No male factor

Exclusion criteria

Exclusion criteria: Unable to give informed consent Background disease Immature oocyte lower than 4 Infectious disease human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Hepatitis B.

Design outcomes

Primary

Measure	Time frame
Oocyte maturation. Timepoint: 24 hours. Method of measurement: Detecting polar body under stereoscope.	—

Secondary

Measure	Time frame
Embryo development after ICSI (Intra Cytoplasmic Sperm Injection). Timepoint: 24 and 48 hours after ICSI. Method of measurement: 2PN and cell division assessment under stereoscope.;Embryo quality. Timepoint: 48 and 72 hours after ICSI. Method of measurement: Embryo assessment under stereoscope.;Gene expression. Timepoint: 24 hours after treatment. Method of measurement: PCR (Polymerase Chain Reaction).	—

Measure

Time frame

Embryo development after ICSI (Intra Cytoplasmic Sperm Injection). Timepoint: 24 and 48 hours after ICSI. Method of measurement: 2PN and cell division assessment under stereoscope.;Embryo quality. Timepoint: 48 and 72 hours after ICSI. Method of measurement: Embryo assessment under stereoscope.;Gene expression. Timepoint: 24 hours after treatment. Method of measurement: PCR (Polymerase Chain Reaction).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHilda Rastegari

Iranian academic center for education culture and research

rastegari_h@yahoo.com22644755

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026