Poor ovarian response. Asymptomatic postprocedural ovarian failure
Conditions
Interventions
Intervention 1: Intervention group: includes 90 patients with poor ovarian response that will be treated by once injection of autologous menstrual blood stem cells. After cells isolation, culture and
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
Female
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: married women ages between 25-45 years old Picked up equal or less than 3 oocytes in last ovarian stimulation Anti mullerian hormone; less than 1.1 nanogram per milliliter Anteral follicles: less than 5-7 Spermogram: more than 5 million per millilieter normal morphology more than 1%
Exclusion criteria
Exclusion criteria: un treated Thyroid dysfunction Immune disorders History of cancer, chemotherapy and radiotherapy Infected by hepatitis B,C or HIV Severe endometriosis History of ovarian surgery Diabetes Dysfunction of electrolyte or liver tests Psychological problem like depression, high stress an anxiety renal failure disease history of blood trasfusion, anemia or sickle cell anemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of antral follicles in ovary. Timepoint: Before intervention, 3 months and 6 months after cell administration. Method of measurement: Vaginal sonography.;Anti Mullerian hormone level in blood serum. Timepoint: Before intervention, 3 months, 6 months and one year after cell administration. Method of measurement: biochemical assay.;Number and quality of oocytes in intra-cytoplasmic sperm injection cycle. Timepoint: first intra-cytoplasmic sperm injection cycle after intervention. Method of measurement: embryologic evaluation.;Spontaneous pregnancy. Timepoint: up to 3 months after intervention. Method of measurement: beta-HCG assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate. Timepoint: in new intra-cytoplasmic sperm injection cycle after intervention. Method of measurement: Vaginal sonography.;Clinical pregnancy. Timepoint: 6-8 weeks after last menstrual period. Method of measurement: Vaginal sonography.;Live birth. Timepoint: 9 months after pregnancy. Method of measurement: delivery report based on gynecologist comment.;Embryo quality and number. Timepoint: in new intra-cytoplasmic sperm injection cycle after intervention. Method of measurement: embryology report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomaieh Kazemnejad
Iranian academic center for education culture and research
Outcome results
None listed