The effect Allicin and Silybum Marianum on suindicators of muscle damage

Comparison of the effect a period of consumption Allicin and Silybum Marianum supplementation with four weeks wrestling selective training on some of the indicators of muscle damage in trained wrestlers

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180618040131N1

Enrollment

Registered

2018-08-13

Start date

2018-07-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Serum markers of muscle injury.

Interventions

Intervention 1: Intervention group: first, 24 hours after blood sampling, the subjects received 3 tablets 300 mg containing 1/1 mg of allicin for one month each day made in Isfahan Pharmaceutical Com

Eligibility

Sex/Gender

Male

Age

15 Years to 20 Years

Inclusion criteria

Inclusion criteria: Wrestlers who have had a continuous training record of at least five years. At least one championship title has been gained at the provincial level.

Exclusion criteria

Exclusion criteria: Use of anti-inflammatory drugs and vitamin supplements Disorders that increase with supplementation of garlic (such as platelet problems, gastritis, hypotension, inflammation of the oral mucosa)

Design outcomes

Primary

Measure	Time frame
Compare differences in the values of CPK change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of LDH change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of AST change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of ALT change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.	—

Measure

Time frame

Compare differences in the values of CPK change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of LDH change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of AST change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.;Compare differences in the values of ALT change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company.

—

Secondary

Measure	Time frame
Score Muscle soreness. Timepoint: Measurement of muscular sorness At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting).supplementation of allicin and silibium marianum. Method of measurement: Borg Pain Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Sharifian

Islamic Azad University

m-sharifian@iau-arak.ac.ir+98 86 3341 2314

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026