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To study the effect of Metronidazole and Ivermectin in hospitalized patients with COVID-19.

To study the effect of Metronidazole and Ivermectin in the recovery of the infected patients with COVID-19 compared with protocol treatment: triple-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180612040068N1
Enrollment
135
Registered
2021-04-19
Start date
2021-03-05
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronavirus infection. Coronavirus infection, unspecified

Interventions

Intervention 1: The first intervention group is the patients that will intake 0.2 mg / kg body weight daily Ivermectin orally (3 mg tablets) as a single dose. Intervention 2: Control group will receiv

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hospitalized patient with positive corona test

Exclusion criteria

Exclusion criteria: Allergic history to Metronidazole or Ivermectin or hypersensitivity reaction to them during trial. pregnant patients COPD Patients suspected to ILD long history of diabetes cirrhotic patients Epileptic patients patients with sever renal failure ang GFR below 20 participating in another RCT

Design outcomes

Primary

MeasureTime frame
The main consequences of this trial including; the time of disappearance of shortness of breath, the need for oxygen, the reduction of CRP, the normalization of lymphopenia that will be measured by specialists. Also, the effectiveness of each treatment method will be measured based on the length of hospital stay, the likelihood of hospitalization in the ICU, and the likelihood of mortality. Timepoint: Before starting treatment and at the time of discharge, which should not be less than 5 days. Method of measurement: Blood factors with laboratory methods. Temperature with digital thermometer. Blood pressure with mercury sphygmomanometer or digital pulse oximeter. Other cases with direct observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHassan Joulaei

Shiraz University of Medical Sciences

joulaei_h@yahoo.com+98 71 3230 5410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026