ANH effect on hemodynamic and blood transfusion rate in CABG patients

Evaluation of the effect of Acute Normovolemic Hemodilution(ANH) on hemodynamics and blood transfusion rate in patients undergoing on-pump CABG

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180603039966N2

Enrollment

172

Registered

2022-11-12

Start date

2022-11-21

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing On-Pump CABG. Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris

Interventions

Intervention 1: Intervention group: Patients who are admitted to Amir-al-Momenin hospital in Kordkoy and Baqiyatallah hospital in Tehran for elective CABG who undergoes Acute Normovolemic Hemodilution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: CABG candidates with hemoglubin level above 14 g/dL CABG candidates with left Ventricular Ejection Fraction above 35%

Exclusion criteria

Exclusion criteria: Patients refusal to participate History of cerebrovascular accident(ischemic or hemorrhagic) History of carotid stenosis History of ischemia or active bleeding(GI bleeding, mesenteric ischemia, claudication) History of renal failure History of liver failure

Design outcomes

Primary

Measure	Time frame
Need for blood transfusion. Timepoint: Will be recorded during surgery and until the discharge from the ICU. Method of measurement: Number of packed cell transfused.	—

Secondary

Measure	Time frame
Mean Arterial Pressire(MAP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Systolic Blood Pressure(SBP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Diastolic Blood Pressure(DBP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Urine Output(U/O). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Urinary drainage Bag.;Central Vein Pressure. Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: CVP Manometer set.;Arterial Blood PH. Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.;Partial pressure of oxygen(Pao2). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.;Partial pressure of carbon dioxide (PaCO2). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.	—

Measure

Time frame

Mean Arterial Pressire(MAP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Systolic Blood Pressure(SBP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Diastolic Blood Pressure(DBP). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Transducer via Arterial line catheter.;Urine Output(U/O). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: Urinary drainage Bag.;Central Vein Pressure. Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: CVP Manometer set.;Arterial Blood PH. Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.;Partial pressure of oxygen(Pao2). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.;Partial pressure of carbon dioxide (PaCO2). Timepoint: Will be recorded during surgery and also at 0, 6, 12, 24 hours after the surgery, And if necessary, will be assessed PRN. Method of measurement: ABG Analyzer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirali Jabbari

Gorgan University of Medical Sciences

dr.a.jabbari@gmail.com+98 17 3245 2651

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026