The effect of oocyte per-incubation time on the cumulus gene profile

Evaluation of gene expression profile in human cumulus cells influenced by different oocyte Pre-incubation times in infertile patients under the treatment in assisted reproduction technology cycles.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180603039965N1

Enrollment

Registered

2018-07-27

Start date

2018-07-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Determination of optimal condition to elevate invitro fertilization rate.

Interventions

Intervention 1: Intervention group 1: 0 hours oocyte pre- incubation before intracytoplasmic sperm injection. Intervention 2: Intervention group 2: 3 hours oocyte pre- incubation before intracytopla

Eligibility

Sex/Gender

Female

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: patients who are in the agonist cycle infertile women with tubal factor normal semen analysis according to WHO 2010

Exclusion criteria

Exclusion criteria: pelvic acute infection coagulation disorder cervicitis and vaginitis cervix malignancy BMI>35 endometriosis(grade 3 &4) polycystic ovarian syndrome oocyte number less than 2 and more than 15

Design outcomes

Primary

Measure	Time frame
Gene expression profile of cumulus cells. Timepoint: At the beginning and 3 hours after pre- incubation. Method of measurement: RNA Sequencing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Mehdizadeh

Iran University of Medical Sciences

zandieh.z@iums.ac.ir+98 21 8862 2689

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026