Efficacy of crucos sativus in Treatment of premenstrual symptoms in comparison with commonly used medicine

Efficacy of crucos sativus in Treatment of premenstrual disphoric disorder in 18-45 year old female in comparison with fluoxetine : A double blind randomized placebo control clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180602039946N1

Enrollment

120

Registered

2018-11-23

Start date

2017-04-21

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

premenstrual dysphoric disorder. Other specified mood [affective] disorders

Interventions

Intervention 1: Intervention group 1: People who received saffron,15mg twice a day.Saffron is provided by pharmacy expert of Esfahan university pharmacy center from Novin saffron company and they woul

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: having the DSM5 criteria for PMDD age between 18-45 BMI between 19.8_25 regular menses cycle (21-35 days) menses between 3-10 days consent and cooperation during the project not having other mood and thought disorder

Exclusion criteria

Exclusion criteria: Pregnancy

Design outcomes

Primary

Measure	Time frame
Mood state. Timepoint: At first interview for those who have the including criteria it is filled by patient and researcher and it will be checked prompt after two menstrual cycles's ending depends on its duration between 42-70 days. Method of measurement: Hamilton scale.;Severity of premenstrual symptoms. Timepoint: at first interview for those who have the including criteria it is filled by patient and researcher and it will be checked prompt after two menstrual cycles's ending depends on its duration between 42-70 days. Method of measurement: daily record of severity of problems.	—

Measure

Time frame

Mood state. Timepoint: At first interview for those who have the including criteria it is filled by patient and researcher and it will be checked prompt after two menstrual cycles's ending depends on its duration between 42-70 days. Method of measurement: Hamilton scale.;Severity of premenstrual symptoms. Timepoint: at first interview for those who have the including criteria it is filled by patient and researcher and it will be checked prompt after two menstrual cycles's ending depends on its duration between 42-70 days. Method of measurement: daily record of severity of problems.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fatemeh Rajabi

Esfahan University of Medical Sciences

fara@gmail.com+98 31 3224 0140

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026