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Effect of topical fluorouracil on vitiligo

Therapeutic effects of topical fluorouracil on vitiligo lesions

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180602039939N1
Enrollment
25
Registered
2021-02-24
Start date
2021-03-21
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: first intervention group: A vitiligo lesion on patient's limbs. Microneedling with 1 mm depth following 30 minutes of 5 Fluorouracil closed bandage on the lesion. I

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to No maximum

Inclusion criteria

Inclusion criteria: Age above 10 years Refractory lesions after 3 month of NB-UVB therapy Lesions distal to elbow/knee (except palms and soles) Signed written informed consent

Exclusion criteria

Exclusion criteria: Active cobner phenomenon at the lesion site Active infection at the lesion site Lesions more than 10 cm Pregnancy/breastfeeding Bleeding diseases Immunosuppress patients

Design outcomes

Primary

MeasureTime frame
Re-pigmentation ratio;. Timepoint: Each 2 weeks until 3 months. Method of measurement: Scoring according to the dermatologist diagnosis.

Secondary

MeasureTime frame
Re-pigmentation start time. Timepoint: Each 2 weeks until 3 months. Method of measurement: Scoring according to dermatologist diagnosis.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSadegh Vahabi

Mashhad University of Medical Sciences

vahabis@mums.ac.ir+98 51 3878 6692

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026