Evaluation of the effect of corticosteroid injection in knee replacement

Evaluation of the effect of corticosteroid injection on respiratory indices and vital signs after cement use in knee replacement

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180528039883N3

Enrollment

200

Registered

2021-08-09

Start date

2021-06-21

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Cement Implantation Syndrome.

Interventions

Intervention 1: Intervention group: One venous infusion of one 100 mg/2 ml ampoule of ABURAIHAN Co. hydrocortisone during the cement implantation. Intervention 2: Control group: No venous injection of

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years Need for Arthroplasty Willingness to participate in the study

Exclusion criteria

Exclusion criteria: History of dementia or psychiatric and psychological disorders that affect decision-making power

Design outcomes

Primary

Measure	Time frame
Percentage of patients with high heart Rate. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Heart Monitoring.;Percentage of patients with blood pressure drop. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Sphygmomanometer.;Percentage of patients with oxygen saturation drop. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Pulse Oxymeter.;PCO2. Timepoint: half an hour after implanting cement. Method of measurement: Arterial Blood Gas.	—

Measure

Time frame

Percentage of patients with high heart Rate. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Heart Monitoring.;Percentage of patients with blood pressure drop. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Sphygmomanometer.;Percentage of patients with oxygen saturation drop. Timepoint: Before anesthesia, before implanting cement, immediately after implanting cement, and half an hour after implanting cement. Method of measurement: Pulse Oxymeter.;PCO2. Timepoint: half an hour after implanting cement. Method of measurement: Arterial Blood Gas.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Yeganeh

Iran University of Medical Sciences

yeganeh.a@iums.ac.ir+98 21 6653 9233

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026