Thin endometrium. Female infertility of uterine origin
Conditions
Interventions
A study of 12 women with at least two implantation failures and endometrial thickness <6 mm after 25–30 days of estradiol without control group, Protocol: estradiol/ASA with dose escalation, vaginal e
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women 20-45 years old Having at least one good grade embryo for transfer Body mass index (BMI) 22–29kg/m2
Exclusion criteria
Exclusion criteria: Uterine anomaly Uterine polyps or myomas Moderate or severe uterine adhesions Precautions and contraindications for using estradiol Uterine infections Uncontrolled systemic diseases Suspected of malignancy Alcohol or drug abuse Adenomyosis Critical thrombocytopenia Hypofibrinogenemia Sepsis Chronic liver disease and anticoagulant therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety )Evaluation of unwanted side effects such as infection, diarrhea, central nervous system disorders, arrhythmia, urticaria/dermatitis, vascular disorders, fever, anemia, constipation, metabolic disorders, fatigue, nausea, seizures, insomnia, and vomiting,...). Timepoint: Immediately after injection, one hour, one week, one month and six months after injection. Method of measurement: Consultation, vital signs control with examination, mercury sphygmomanometer and thermometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness. Timepoint: One week, two weeks, and three weeks later. Method of measurement: Ultrasound.;Dosage of estradiol used. Timepoint: Once after the treatment period is completed. Method of measurement: Review of patient records.;Duration of endometrial preparation. Timepoint: Once after the treatment period is completed. Method of measurement: Review of patient records.;Endometrial grade (B, A and C). Timepoint: Once after the treatment period is completed. Method of measurement: Ultrasound.;Biochemical pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: Pregnancy test.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound.;Clinical pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound.;Ongoing pregnancy rate. Timepoint: At week 16 of pregnancy. Method of measurement: Ultrasound.;Live birth rate. Timepoint: Termination of pregnancy after twenty weeks. Method of measurement: Patient declaration.;Miscarriage rate. Timepoint: Termination of pregnancy before 20 weeks. Method of measurement: Patient declaration. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Vojoudi
Rasht University of Medical Sciences
Outcome results
None listed