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Sequential embryo transfer in repeated implantation failure

The pregnancy outcome of sequential embryo transfer compared to blastocyst embryo transfer on patients with repeated implantation failure in frozen and thawed embryo transfer cycles-randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180528039878N4
Enrollment
200
Registered
2021-12-25
Start date
2021-12-27
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Repeated implantation failure. Female infertility

Interventions

Intervention 1: Intervention group: In consecutive embryo transfer, first
2 embryos of top and good quality will be transferred on day 2 or 3. The embryos will then be cultured to the blastocyst stage and 1 blastocyst will be transferred on day 5 or 6. Intervention 2: Contr

Sponsors

Mehr medical institute
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age less than 40 years History of two or more repeated implantation failure cycles Presence of 3 top and good quality embryos

Exclusion criteria

Exclusion criteria: Recent uterine pathologies that disrupt the pregnancy process Preimplantation genetic diagnosis cycles Lack of embryo development until the blastocyst stage

Design outcomes

Primary

MeasureTime frame
Biochemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: Blood test.;Clinical pregnancy. Timepoint: Six weeks after embryo transfer. Method of measurement: Ultrasound.;Implantation. Timepoint: Six weeks after embryo transfer. Method of measurement: Ultrasound.;Multiple pregnancy. Timepoint: During pregnancy. Method of measurement: Ultrasound.

Secondary

MeasureTime frame
Ongoing pregnancy. Timepoint: Twelve weeks following embryo transfer. Method of measurement: Ultrasound.;Early pregnancy loss. Timepoint: Twelfth week of pregnancy. Method of measurement: Ultrasound.;Late miscarriage. Timepoint: Twelfth to twenty-eighth week. Method of measurement: Ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Mehrafza

Mehr Medical Institute

marzieh.mehrafza@gmail.com+98 13 3376 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026