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Evaluation of the efficiency of clomiphene citrate plus letrozole on intrauterine insemination outcome

Evaluation of the efficiency of clomiphene citrate plus letrozole gonadotropins for superovulation in patients undergoing intrauterine insemination: a randomized trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180528039878N1
Enrollment
501
Registered
2018-07-19
Start date
2018-08-23
Completion date
Unknown
Last updated
2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: Group A will receive clomiphene citrate (100 mg, Iran Hormone) on cycle day 3-7 ( for 5 days). Intervention 2: Intervention group: Group B will receive Letrozole (5

Sponsors

Mehr medical institute
Lead Sponsor
Rasht University of Medical Sciences
Collaborator

Eligibility

Sex/Gender
Female
Age
No minimum to 38 Years

Inclusion criteria

Inclusion criteria: Age = 38 years• Basal FSH level <10 Patients without history of allergic reactions to clomiphene Mild male factor infertility Unexplained infertility Anovolatory patients who have not been pregnant despite the use of ovulation induction techniques and appropriate follicles

Exclusion criteria

Exclusion criteria: No response to ovulation induction Patients with large number of follicles who cannot receive hCG

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy. Timepoint: Seven weeks after intrauterine insemination. Method of measurement: Observation of gestational sac on transvaginal ultrasound.

Secondary

MeasureTime frame
Number of follicles = 18 mm. Timepoint: On hCG administration day. Method of measurement: By transvaginal ultrasound.;Follicular size on hCG day. Timepoint: On hCG administration day. Method of measurement: By transvaginal ultrasound.;Duration of ovarian stimulation. Timepoint: At the end of ovarian stimulation. Method of measurement: Number of days.;Endometrial thickness on hCG administration day. Timepoint: On hCG administration day. Method of measurement: By transvaginal ultrasound.;Gonadotropin dosage. Timepoint: At the end of ovarian stimulation. Method of measurement: International Units.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Mehrafza

Mehr medical institute

marzieh.mehrafza@gmail.com+98 13 3376 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026