Stomatitis caused by radiotherapy for head and neck. Oral mucositis (ulcerative)
Conditions
Interventions
Intervention 1: Intervention group: Combined folic acid solution containing (folic acid = 100 mg, NaHCO3=38 mg, propyl parahydroxybenzoate = 25 mg, methyl parahydroxy benzoate = 50 mg, conc peppermint
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Satisfied to participate in the study The mucous membrane is healthy and free from mucosal lesions and oral and dental problems Age of 18 to 60 years Receive external radiotherapy and radiation at a dose of 180 CGy per day for one hour During the study, do not use any mouthwash and other medication for oral ulcers Not having dentures
Exclusion criteria
Exclusion criteria: Having immunodeficiency disease and having leukopenia and leukocytosis Having underlying illness (diabetes, kidney disease, liver disease) There is a history of tobacco use, including smoking, hookah, and narcotics in the last month Chemotherapy drugs receive simultaneous radiotherapy during the study Receives sedative During the study, do not use any mouthwash and other medication for oral ulcers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of stomatitis. Timepoint: Before the start of the first and seventh and fourteenth days of Radiotherapy, the incidence of stomatitis, pain, mouth ulcers in patients' records. Method of measurement: The World Health Organization standard tool for measuring stomatitis, pain visual analog scale (Visual Analogue Scale), measuring instruments sores (oral mucositis assessment scale). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Mousa Mahdizadeh
Mashhad University of Medical Sciences
Outcome results
None listed