Chronic pain and mobility function of knee joint pain. Pain in joint
Conditions
Interventions
Intervention 1: Control group: Piroxicam Gel (0.5%). Intervention 2: Intervention group: Piroxicam Gel (0.5%)+Nanotransfersomal Piroxicam Emulgel.
Sponsors
Daroosazan Sorena Exir Pharmaceutical Company
Eligibility
Sex/Gender
All
Age
25 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with osteoarthritis or rheumatoid arthritis presenting pain in one or both knee joints Chronic knee joint pain persisting for more than 3 months Non-responsiveness to initial oral or topical treatments (including standard medications). Willingness and informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Use of any analgesic medications (oral, injectable, or suppository forms), including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), narcotics, or herbal products with proven analgesic activity (e.g., black seed oil) during the 7-day study period or in the weeks preceding the study Known hypersensitivity or allergy to piroxicam or any components of the emulgel formulation Presence of active wounds or skin lesions on the knee area Severe systemic diseases that may influence study outcomes Pregnancy or lactation Inability or unwillingness to cooperate or complete questionnaires required in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain level in knee joint. Timepoint: The pain level is measured every 24 hours. Method of measurement: The pain is evaluated based of emotional, perceptional and sensational variables of McGill questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain level at rest and function. Timepoint: Evaluation every 24 hours. Method of measurement: Evaluation with McGill or VAS.;Onset of painkilling action. Timepoint: every 24 hours. Method of measurement: Record of onset of action (insight of patient/volunteer).;Systemic/topical adverse effects/reactions. Timepoint: Every 24 hours. Method of measurement: Patient/volunteer insight survey. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Ali Nazarinia
Shiraz University of Medical Sciences
Outcome results
None listed