Effect of prophylaxis antibiotic before and during operation on maternal and neonatal outcomes

Comparison of the effect of prophylaxis antibiotic before and during operation on maternal and neonatal outcomes in pregnant women candidate for elective cesarean section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180525039834N1

Enrollment

360

Registered

2018-06-10

Start date

2018-06-21

Completion date

Unknown

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective cesarean section. Delivery by elective caesarean section

Interventions

Intervention 1: Intervention group: Cefazolin 2 gr, 15-30 minutes before surgery. Intervention 2: Control group: Cefazolin 2 gr, 15-30 minutes after exit the placenta.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Gestational age greater than 34 weeks

Exclusion criteria

Exclusion criteria: Antibiotic use in the past two weeks The temperature greater than 38 at least 2 times at intervals of 6 hours in the axillary region during surgery Sensitivity to cefazolin antibiotics

Design outcomes

Primary

Measure	Time frame
Endometritis. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Wound infection. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Urinary tract infection. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Apgar Score. Timepoint: At birth. Method of measurement: Clinical evaluation.;Hypothermia. Timepoint: At birth. Method of measurement: Clinical evaluation.;Tachypnea. Timepoint: At birth. Method of measurement: Clinical evaluation.	—

Measure

Time frame

Endometritis. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Wound infection. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Urinary tract infection. Timepoint: Before surgery and 1 week and 2 weeks after surgery. Method of measurement: Clinical evaluation.;Apgar Score. Timepoint: At birth. Method of measurement: Clinical evaluation.;Hypothermia. Timepoint: At birth. Method of measurement: Clinical evaluation.;Tachypnea. Timepoint: At birth. Method of measurement: Clinical evaluation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanise Akbarzade

Shahroud University of Medical Sciences

akbarzade@shmu.ac.ir+98 23 3239 4499

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026