Effect of Vitamin D3 in patients with Traumatic Brain Injury

Effect of high dose vitamin D3 on IL-ß blood level in patients with moderate to severe Traumatic Brain Injury (TBI): Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180522039777N2

Enrollment

Registered

2022-11-12

Start date

2022-11-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe Traumatic brain injury. Multiple injuries of head

Interventions

Intervention group: Patients in the intervention group receive one vitamin D3 ampoule with a dose of 300,000 units intramuscularly.

Eligibility

Sex/Gender

All

Age

18 Months to 65 Years

Inclusion criteria

Inclusion criteria: TBI patients with age range of 18 to 65 years GCS score between 3 and 12 TBI patients with vitamin D level less than 30 ng/ml

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum level of Interleukin-1-beta. Timepoint: The first day of study entry and 72 hours later. Method of measurement: Patient serum sample.	—

Secondary

Measure	Time frame
Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). Timepoint: From the first day of sampling for 7 consecutive days. Method of measurement: Blood cell count.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr mohammad Sistanizad

Shahid Beheshti University of Medical Sciences

sistanizadm@yahoo.com+98 21 8820 0118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026