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Pretreatment pentoxifylline and control of post operative pain

The effect of Pretreatment of oral pentoxifylline administration on post-operative pain and development of hyperalgesia in patient under appendectomy surgery

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180522039773N1
Enrollment
90
Registered
2018-11-24
Start date
2018-02-20
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain.

Interventions

Intervention 1: Intervention group: A pentoxifylline dose of 10 mg / kg is given orally in half an hour before anesthesia. Intervention 2: Placebo group: One dose of placebo is given orally to patient

Sponsors

Sabzevar University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 45 Years

Inclusion criteria

Inclusion criteria: appendectomy surgery Age range 15-45 years Interested in participating in the study

Exclusion criteria

Exclusion criteria: Addiction to cigarettes, alcohol and drugs mental illness or a specific disease Sensitivity to Pentoxifylline Liver disease Age over 45 and under 15 years of age

Design outcomes

Primary

MeasureTime frame
Pain Scale. Timepoint: 6- 12-18-24 Hours after sergury. Method of measurement: VAS test.;Hyperalgesia. Timepoint: 12-24 Hours after sergury. Method of measurement: von Frey test with von frey filaments (180 g).;Ramsay Relaxation Scale. Timepoint: 12-24 Hours after sergury. Method of measurement: Ramsey Relaxation Questionnaire.;TNF alpha. Timepoint: 24 hours after sergury. Method of measurement: ELISA.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamad Nazemi

Sabzevar University of Medical Sciences

samadnazemi@gmail.com+98 0514018368

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026