Acute Respiratory Distress Syndrome. Acute respiratory distress syndrome
Conditions
Interventions
Intervention 1: Intervention group: they receive magnesium sulfate 50% 10ml ampoule from Samen Pharmaceutical Company in the amount of one dose and for one time intravenously dissolved in normal salin
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients aged over 16 years Admitted to the intensive care unit following trauma without brain injury Meeting the criteria for severe acute respiratory distress syndrome based on the Berlin criteria Intubated and requiring non-depolarizing muscle relaxants
Exclusion criteria
Exclusion criteria: Presence of life-threatening signs (oxygen saturation less than 92 percent despite mechanical ventilation, cyanosis, silent chest) Bradycardia Cardiac arrhythmia Hypotension (systolic blood pressure less than 90 mmHg) Coma Inability to provide written consent by the patient's legal representative
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In-hospital mortality. Timepoint: After finishing hospitalization. Method of measurement: Checking the presence of a death certificate.;Length of hospitalization in the intensive care unit. Timepoint: After discharge from the intensive care unit. Method of measurement: Refer to the information contained in the patient's file to accurately record the duration.;Duration of use of invasive mechanical ventilation. Timepoint: After extubation. Method of measurement: Refer to the information contained in the patient's file to accurately record the duration.;Partial pressure of oxygen in arterial blood. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of arterial blood gas samples.;Ratio of partial pressure of oxygen in arterial blood to the fraction of inspiratory oxygen concentration. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Measurement of partial pressure of oxygen in arterial blood: Laboratory examination of arterial blood gas samples. Measurement of inspiratory oxygen fraction: refer to the information of the ventilator.;PH of arterial blood sample. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of arterial blood samples.;Serum magnesium level. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of peripheral blood samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum sodium level. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of peripheral blood samples.;Serum potassium level. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of peripheral blood samples.;Serum calcium level. Timepoint: The day of the intervention, the first day and the second day after the intervention. Method of measurement: Laboratory examination of peripheral blood samples.;Dose of corticosteroids received in the intensive care unit. Timepoint: After discharge from the intensive care unit. Method of measurement: Refer to the information in the patient's file to accurately record doses.;Daily receiving diuretics in the intensive care unit. Timepoint: After discharge from the intensive care unit. Method of measurement: Refer to the information contained in the patient's file to accurately record the number of days of receiving diuretics. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamadreza Habibzadeh Siyahrood Kolaee
Esfahan University of Medical Sciences
Outcome results
None listed