Investigating the effect of vitamin A and coronet in the treatment of kidney scar

Investigating the effect of vitamin A and Corticosteroid in reducing renal scarring in patients with acute pyelonephritis: a double-blind randomized clinical trial study with a control group

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180519039715N5

Enrollment

Registered

2023-04-16

Start date

2023-05-05

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pyelonephritis. Nonobstructive reflux-associated chronic pyelonephritis

Interventions

Intervention 1: Intervention group: Receiving vitamin A, manufactured by Osoeh Pharmaceutical Company of Iran, by injection during three days of hospitalization, three times in three days, and each in

Eligibility

Sex/Gender

All

Age

3 Months to 6 Years

Inclusion criteria

Inclusion criteria: Diagnosis of acute pyelonephritis and hospitalization. Children aged 3 months to 6 years, All urine cultures are positive.

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study, neurogenic bladder, obstructive uropathy, Vitamin A intolerance, Symptoms of vitamin A poisoning,

Design outcomes

Primary

Measure	Time frame
Change in severity of kidney scar. Timepoint: The beginning of the study (before the intervention), 6 months after the intervention. Method of measurement: by dimercaptosuccinic acid (DMSA) scan.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrnoush Mohamadi Kamalvand

Kermanshah University of Medical Sciences

mehrnooshmohammadi.k1367@gmail.com+98 83 3826 4513

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026