Comparison of radiofrequency with ozone in improving the symptoms of knee osteoarthritis

Comparison of the Radioferequency and intraarticular ozone on improving the osteoarthritis symptoms of knee joint

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180518039700N3

Enrollment

Registered

2021-09-12

Start date

2021-07-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis. Primary generalized (osteo)arthritis

Interventions

Intervention 1: Intervention group:Ozone group: 15 cc of ozone 35 micro-grams per millilitre will be injected. After injection, flexion and extension movements will be performed for better distributio

Eligibility

Sex/Gender

All

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: Median knee osteoarthritis (Grade 2 or 3 based on Kellegren and Lawrence knee radiography) Patients over 45 years old Satisfaction of patients participating in the study Failure to respond to conservative and physiotherapy treatments over the past 6 months

Exclusion criteria

Exclusion criteria: Severe osteoarthritis (Grade 4 candidates for joint replacement surgery) Rheumatic disease Received previous corticosteroids 3 months ago Clearly visible deformity of the varus or valgus of the knee Severe knee flexion contraction Ankylosis Psychological disorders Drug dependence Hyperthyroidism Thrombocytopenia Pregnancy

Design outcomes

Primary

Measure	Time frame
Physical performance. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: WOMAC questionnaire(Western Ontario and McMaster Universities Osteoarthritis Index questionnaire).;Intensity of pain. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: VAS (Visual Analog Scale) will be measured at rest and after 6 meters of walking.;Patient satisfaction. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: Question from the patient (excellent, good, acceptable and unsatisfactory).	—

Measure

Time frame

Physical performance. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: WOMAC questionnaire(Western Ontario and McMaster Universities Osteoarthritis Index questionnaire).;Intensity of pain. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: VAS (Visual Analog Scale) will be measured at rest and after 6 meters of walking.;Patient satisfaction. Timepoint: At the beginning of the study, in 4th session of ozone therapy and 2nd session of radio frequency (at the end of sessions of both methods) and one month after the end of sessions. Method of measurement: Question from the patient (excellent, good, acceptable and unsatisfactory).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSolmaz Fakhari

Tabriz University of Medical Sciences

solmaz_fakhari@yahoo.com+98 41 3334 1994

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026